This study assessed the reliability and concurrent validity of the prenatal section of the Postpartum Depression Predictors Inventory–Revised for 250 pregnant women receiving prenatal care in Mexico. The Postpartum Depression Predictors Inventory–Revised has shown adequate psychometric properties for English-speaking perinatal women, but no similar data have been reported for Spanish-speaking samples. The results show that the Postpartum Depression Predictors Inventory–Revised is highly reliable and exhibits adequate concurrent validity compared to the Edinburgh Postnatal Depression Scale. These findings suggest that the Postpartum Depression Predictors Inventory–Revised can be a reliable instrument in prenatal care services for detecting risk factors for perinatal depression in Mexican women and potentially in other Spanish-speaking populations.