Assisted reproductive technologies have engendered new familial arrangements, some of which challenge traditional assumptions about the relationship between biology and social roles. In this article, we report on the first survey ever conducted of parents of former egg and sperm donors. Twenty-two men and women participated in a survey conducted by the Donor Sibling Registry, a worldwide registry facilitating mutual-consent contact among donor offspring, their gamete donors, and other family members. We report on their feelings and thoughts on learning that their child donated gametes and on learning that they have a grandchild (or grandchildren) via gamete donation. We also examine what type of relationship, if any, participants have formed with their donor-conceived grandchildren, as well as their advice to other parents of donors. We conclude with questions and suggestions for future research into this newly emerging terrain of family relations.