Objective This randomized controlled investigation examined the effectiveness of a self‐help bibliotherapy format of the evidence‐based mindfulness‐based stress reduction (MBSR) intervention. Method College students seeking stress reduction were randomly assigned to a 10‐week MBSR bibliotherapy intervention group (n = 47) or a no‐treatment control group (n = 45). Self‐report measures were collected at baseline and postintervention. Results A total of 25 bibliotherapy and 43 control group participants provided final data following the intervention period. Compared to the control group, bibliotherapy participants reported increased mindfulness following the intervention. Significant decreases on measures of depression, anxiety, stress, perceived stress, and anxiety sensitivity also were reported postintervention as well as increased quality of life in physical health, psychological, and environmental domains. No statistically significant group effects were found for social relationships quality of life domain, worry, and experiential avoidance measures. Conclusion This MBSR workbook may provide an acceptable and effective alternative for motivated individuals seeking to reduce stress, at least for a select group of individuals who are willing and able to sustain participation in the intervention.