Mothers’ experiences with their firstborn child may be relevant for understanding the further growth of families. Dutch women (N = 795) reported on motherhood experiences during pregnancy and the first year. Direct effect models of mood symptoms, birth expectations, and child negative reactivity, and indirect effect models via parenting self-efficacy were tested to discriminate mothers who had, wanted, were undecided, and did not want a second child at a 2-year follow-up. Results indicated that mothers with two children had higher prenatal parenting self-efficacy and less postnatal trait anxiety compared with those who wanted a second child. There was no evidence for indirect effects of mood symptoms, birth expectations, or negative reactivity on having a second child via parenting self-efficacy. Also, mothers who did not want a second child had more unmet expectations regarding childbirth and, surprisingly, reported less child negative reactivity than other mothers. Implications of these findings are discussed.