This article aims at introducing the research on social work practice in Egypt and the Arab World as a thematic topic. It has started with the essence of the current Arab World and its definition. Social work practice and models of social work intervention in this specific region have been described in terms of its specific and topographic nature. Three main contributors and players to research on social work practice have been included namely social work practitioners, academic social work researchers, and doctoral dissertations granted by Western universities to Arabs. The discussions and implications to research on social work practice in Egypt and the Arab World have been addressed.