Natural enemies (NEs) provide an important ecosystem service by preying on variety of pests in agricultural crop production systems. Current management practices of both primary and secondary pests in agricultural production principally rely on the use of pesticides with associated negative social and environmental consequences/externalities. Excessive use of pesticides against primary pets can remove NEs from the agro‐ecosystem and amplify susceptibility of the system to outbreaks of secondary pests. The combined effect of NEs on primary and secondary pests has received limited attention. This study uses an intraseasonal bioeconomic model to explicitly take into account biological interactions among primary pests, secondary pests, and NEs assuming decision makers’ profit maximizing behavior. The model explicitly captures the opportunity cost of injury to NE in terms of both primary and secondary pest suppression by NE. The results show that in the context of the green peach aphid (primary pest) and two‐spotted spider mite (secondary pest) in potato production, inclusion of NE into pest mitigation strategy can increase returns by 2%.