While career decision ambiguity tolerance (CDAT) has been repeatedly shown to play a salient role in career decision-making, a potential revision of its measurement model has been indicated in past research. More importantly, it remains less clear as to what individual characteristics are associated with high CDAT. We examined a four-factor model of CDAT (i.e., preference, tolerance, confidence, and aversion) and its associations with adherence to the realistic, investigative, artistic, social, enterprise, and conventional (RIASEC) structure and career calling in a sample of college students (N = 248). The results of the current study supported the four-factor model being superior to the original three-factor model in representing the structure of CDAT. It was also found that adherence to the RIASEC structure was positively associated with preference, presence of calling was positively associated with confidence, and search for calling was positively associated with aversion. The implications of the results were discussed with respect to the theory and research of CDAT. Limitations and suggestions for future research were also provided.