The present study examined the cross-cultural validity of instruments used to assess the experience of searching for, having, and living out a calling. Using a sample of 336 Americans and 327 Indians, we used structural equation modeling to assess measurement invariance of three common scales used to measure calling: the Calling and Vocation Questionnaire (CVQ), the Brief Calling Scale, and the Living Calling Scale. Results showed partial measurement equivalence for the presence scale of the CVQ, indicating that it may be a valid measurement of within-group differences among Indian participants. Analyses on remaining scales showed borderline support for equivalence of factor structure and failed to demonstrate validity of cross-cultural comparisons. Implications for researchers and clinical practitioners are discussed.