Introduction The paper presents a case study that critically assesses the role of global strategy ‘Public Health on the Frontline 2014–2015’ (‘the Strategy’) in supporting Merlin and Save the Children's organisational change and future programme of the combined organisation in Myanmar. Materials and methods Research was undertaken in 2014 in Myanmar. Twenty‐six individual and three group interviews were conducted with stakeholders, and 10 meetings relevant to the country organisational transition process were observed. A conceptual framework was developed to assess the role of the global strategy in supporting the country change process. Results Several positive aspects of the global strategy were found, as well as critical shortcomings in its support to the organisational change process at country level. The strategy was useful in signalling Save the Children's intention to scale up humanitarian health provision. However, it had only limited influence on the early change process and outcomes in Myanmar. Conclusions Results highlight several aspects that would enhance the role of a global strategy at country level. Lessons can be applied by organisations undertaking a similar process. Copyright © 2016 John Wiley & Sons, Ltd.