Mind–body interventions can improve vulnerabilities that underlie smoking behavior. The characteristics of smokers who use mind–body medicine have not been explored, preventing the development of targeted interventions. Patients (N = 593) presenting to a mind–body medicine clinic completed self-report measures. Patients were 67 percent never smokers, 27 percent former smokers, and 6 percent current smokers. Current smokers were younger; more likely to be single, unemployed, or on disability; and report greater depression symptoms, greater pain, and lower social support (ps < .05).Current smokers who use mind–body medicine have unique psychosocial needs that should be targeted in mind–body smoking cessation interventions.