This study investigated the association among friendship, global self-worth, and domain-specific self-concepts in 102 university students with and without learning disabilities (LD). Students with LD reported lower global self-worth and academic self-concept than students without LD, and this difference was greater for women. Students with LD also reported that they had more stable friendships than students without LD. Students with LD were more likely to have higher global self-worth and self-perceptions of social acceptance if they had stable friendships and had relationships where they communicated spontaneously and frankly. None of the friendship variables predicted academic self-concept. Thus, having stable and intimate friendships is a protective factor in relation to global self-worth and social self-concept in university students with LD.