This article describes an investigation of a boundary control for vibration suppression of an axially moving accelerated or decelerated belt system with input saturation. Firstly, after considering the effects of the high acceleration or deceleration and unknown distributed disturbance, an infinite-dimensional model of the belt system is described by a nonhomogeneous partial differential equation and a set of ordinary differential equations. Secondly, by synthesizing boundary control techniques and Lyapunov’s direct method, a boundary control is developed to suppress the belt’s vibration and to stabilize the belt system at its equilibrium position globally; an auxiliary system is proposed to compensate for the nonlinear input saturation characteristic; a disturbance adaptation law is employed to mitigate the effects of unknown boundary disturbance; and the S-curve acceleration/deceleration method is adopted to plan the belt’s axial speed. Thirdly, with the proposed boundary control, the wellposedness of the closed-loop belt system is mathematically demonstrated and uniformly bounded stability of the closed-loop system is achieved without any discretization of the system dynamic model. Finally, simulation results are presented to verify the validity and effectiveness of the proposed control scheme.