The search for necessary and sufficient causes of some outcome of interest, referred to as configurational comparative research, has long been one of the main preoccupations of evaluation scholars and practitioners. However, only the last three decades have witnessed the evolution of a set of formal methods that are sufficiently elaborate for this purpose. In this article, I provide a hands-on tutorial for qualitative comparative analysis (QCA)—currently the most popular configurational comparative method. In drawing on a recent evaluation of patient follow-through effectiveness in Lynch syndrome tumor-screening programs, I explain the search target of QCA, introduce its core concepts, guide readers through the procedural protocol of this method, and alert them to mistakes frequently made in QCA’s use. An annotated replication file for the QCApro extension package for R accompanies this tutorial.