Purpose: The aim of the study was to examine, from an intersectional perspective, how immigrant women with prolonged illness experience the conditions for physical activity. Method: Focus groups were used. Twenty-two women from primary care representing 14 countries were included. Systematic text condensation was applied for analysis. Results: Five conditions were identified: Dual cultures to relate to, Isolation an invisible danger, Keys to physical activity, Physical activity for whom, The power to decide the agenda. Discussion and Conclusion: This study shows the importance of raising the intersectional perspective for immigrant women’s possibilities to perform physical activity. Immigrant women’s vulnerability to power relations and their adjustment to society’s expectations are significant considerations to be aware of. Implications for Practice: Our findings emphasize the significance of collaborating in biomedical and psychosocial issues, considering that the obstacles are more comprehensive than society assumes regarding prior knowledge, isolation, and cultural rules.