Though historically confined to hospital settings, methicillin-resistant Staphylococcus aureus (MRSA) has received increasing attention in the wider community, particularly among athletes. A 2007–2008 investigation in Nebraska concluded that MRSA skin infections were an emerging problem among the state’s student athletes. Statewide surveillance was subsequently conducted during 4 school years (2008–2012) to estimate incidence of skin and soft tissue infections (SSTI) consistent with MRSA among student athletes. High school athletic officials completed Internet-based surveys following winter and fall sport seasons. Over 3 school years, incidence estimates per 10,000 athletes decreased substantially from 20.9 (2008–2009) to 11.3 (2010–2011) among football players and from 60.8 (2008–2009) to 28.1 (2010–2011) among wrestlers. Following the 2011–2012 sport seasons, however, incidence estimates increased to 16.6 per 10,000 football players and 43.3 per 10,000 wrestlers. School nurses should support school officials to prioritize prevention and control efforts for SSTI, including MRSA.