This article sets out a new conceptual framework for investigating how city regionalism is constituted as a variegated set of geopolitical processes operating within and beyond the national state. Our approach highlights: (1) the different forms of territorial politics through which city regionalism is conjoined with broader visions of the national state; (2) the material and territorial arrangements which support such a conjuncture; and (3) the political actors enabling city regionalism and the national state to come together within a geopolitical frame of reference.