Self‐disclosure is a key concept in computer‐mediated communication (CMC) theory and research, but disagreement exists about the impact of CMC, relative to face‐to‐face (FtF) communication, on self‐disclosure. We conducted a meta‐analysis of studies comparing self‐disclosure in CMC and FtF communication to summarize and clarify existing research. We also examined potential moderators of this difference—measure of self‐disclosure, study design (survey or experiment), interaction context (task or social), type of CMC (text‐based or video‐based), and interaction length. Overall, self‐disclosure was higher in FtF communication than in CMC. Measure of self‐disclosure, study design, and type of CMC moderated this difference. Findings suggest mixed support for predictions derived from key CMC theories and a need for CMC theory to more explicitly address self‐disclosure.