The aim of this study was to investigate how dispositional resistance to change and neuroticism could predict shift‐work tolerance (SWT) over a period of 6 months. Electronic questionnaires were completed by 74 shift workers employed in a municipality in Norway in January 2013 (1st wave of data collection) and in June 2013 (2nd wave of data collection). The findings suggest that individual differences, especially neuroticism, can predict SWT over a period of 6 months.