This article introduces a new approach to the study of EU mediation and conflict resolution. It argues that researchers have not fully accounted for the changes underway in the Union's take on mediation. By elucidating the differences between this approach and the already existing literature on EU mediation, the article advocates a practice turn and develops a framework for studying EU mediation as an assemblage of practices. It builds on Latourian assemblage thinking and complements it with the Foucauldian notion of political rationality and techne. This approach is then explored through examining the practices of EU mediation support in Myanmar, which draws attention to the contradictions and a specific set of knowledge claims on peace and conflict, and traces dissident voices and how they inform the use of mediation instruments. In so doing, it demonstrates how a practice‐oriented approach allows us to provide new insights into EU external action.