These conversations between Toni Negri and Sandro Mezzadra (November 2014–October 2015) focus on the politics of Mediterranean boundaries and situate migratory movements across the Mediterranean in the geopolitical context of the Eastern and Southern shore. Looking at the proliferation of wars around the Mediterranean region and reflecting on the legacy of the Arab Uprisings, Mezzadra and Negri revisit the concept of the “autonomy of migration” and critically interrogate its possible contribution to the field of migration and in terms of the current refugee crisis.