--- - |2+ Objectives This article examines the effect of both modern and traditional sexism on vote choice in the 2016 presidential election, and posits that they played a major role in explaining Hillary Clinton's defeat to Donald Trump. Methods Data from the 2016 American National Election Study are analyzed using a logistic regression model. Results Both modern and traditional sexism exerted a statistically significant effect on presidential vote choice in 2016. Indeed, its effect rivaled that of racial resentment and was only exceeded by partisanship. Conclusion While a variety of factors may have cost Hillary Clinton the presidency in 2016, sexism needs to be addressed as one of those factors. More broadly, the findings of this article suggest that women candidates continue to face obstacles and are evaluated differently than men, especially when running for the most visible offices in American politics. - 'Social Science Quarterly, EarlyView. '