The present study examined whether ethnic identity cluster patterns, using Ethnic Identity Scale (EIS) subscale scores, moderated the relationship between perceived stress and depressive symptoms. Participants were 390 Latino adults from a moderately sized Midwestern city. Four ethnic identity cluster patterns were identified through cluster analysis: Achieved Positive, Diffuse Positive, Foreclosed Positive, and Diffuse Negative. Results from a moderated multiple regression analysis indicated a significant interaction effect of ethnic identity clusters (i.e., Achieved Positive vs. Diffuse Negative) and perceived stress on depressive symptoms. Specifically, at lower levels of stress, no significant difference was found; whereas, at higher levels of stress, individuals with Achieved Positive cluster patterns had significantly lower levels of depressive symptoms than individuals with Diffuse Negative cluster patterns. The findings are discussed within the context of ethnic identity theory and the implications for research and clinical conceptualizations.