Guided by a Person x Context cultural framework, this is the first known study to examine the relationship between cultural values and mental health-related outcomes (depressive symptoms and professional psychological help seeking) across diverse interpersonal contexts. Using a quasi-experimental research design, 465 Asian international college students were randomly assigned to report their adherence to the Asian cultural values of emotional self-control and humility during interactions with (a) their families of origin, (b) peers from their country of origin, or (c) American peers. Humility was positively associated with depressive symptoms only during interactions with nonfamily members, and not with family members. Emotional self-control was negatively associated with attitudes toward seeking psychological help only during participants’ interactions with members of their country of origin. Humility was negatively related to psychological help seeking only during participants’ interactions with nonfamily members.