The purpose of this study is to examine the potential mediating role of mothers’ social interactions with their infants in the association between maternal depressive symptoms (MDSs) at three time points and infants’ social skills in Korea. Data were taken from 1,472 infants and mothers of the Public Study of Korean Children. Mothers completed the Kessler 6 to examine MDSs at three time points. Mothers also completed the Parenting Style Questionnaires to assess infants’ social skills. Correlational analyses revealed that mothers who had depressive symptons when infants were 4 months of age were less likely to be responsive and sensitive when mothers interacted with their infants. In addition, sensitive and responsive interactions with their infants were positively correlated with infants’ social skills. Structural equation model analyses showed that mothers’ responsive and sensitive interactions with their infants entirely mediated the association between MDSs at 4 months’ postpartum and infants’ social skills. The findings suggest that the mediating role of sensitive and responsive interactions with their infants in the association betweemn MDSs and infants’ social skills is potentially similar in Asian samples.