Background We examined the effects of home‐delivered cognitive‐behavior therapy (CBT) on depressive symptoms among rural, diverse, and vulnerable older adults. Furthermore, we differentiated depression into its two salient aspects: psychological and somatic. Method Data came from a randomized controlled experiment of CBT on 134 individuals residing in rural Alabama. Results Cognitive‐behavior therapy resulted in significantly lower depressive symptom severity scores. When depressive symptoms were categorized as psychological or somatic, CBT was found to significantly improve the former but not the latter. Notably, there was a trend toward somatic symptom improvement. Conclusion Cognitive‐behavior therapy can be an effective treatment for depression in a hard‐to‐reach group of older adults. Home delivery affords advantages but is also an expensive delivery modality. Diverse older adults responded to the CBT intervention. Copyright © 2013 John Wiley & Sons, Ltd.