Our study investigated gender differences in the long-term effects of education, work experience, agentic personality traits, and number of children on career success (i.e., salary) in medicine. German male and female students (N = 99) were surveyed at a German medical school (T1) and 15 years later (T2). Women interrupted their careers for longer than men (d = .92). Men had a substantially higher income at T2 (d = 1.07). Career interruptions, agentic personality traits, and high school grades were significant predictors of salary for both sexes. High final grades at medical school were significantly and positively related to salary but only for men. Low final grades at medical school and number of children predicted the length of career interruptions. For women, number of children was significantly and positively related to career interruptions. For men, number of children was significantly but negatively related to career interruptions. The findings corroborate research from other occupational fields, showing that a discontinuous work history has a negative influence on career success and that human capital variables are better rewarded for men than for women.