The southern subculture of violence is a theoretical perspective that has been examined by numerous scholars in an attempt to explain the high rates of violence in the Southern United States. Research over the past several decades has converged on a few explanations for this violence, including a culture of honor, a frontier mentality, and a presence of evangelical Protestantism. The primary focus of this research has been on either male offending or race disaggregated offending. The influence of the southern subculture of violence on female offending has only recently come to the forefront and has concentrated on relatively recent time periods (1990s to present). The present study examines the effect of southern culture on female-perpetrated homicides in the 1970s, a time when female offending was on the rise. Utilizing a southern subculture of violence index, our county-level negative binomial regression analysis finds that in counties with more Southern-born residents and a higher presence of evangelical Protestantism, female homicide offending is higher. Implications of these results and avenues for future research are discussed.