The main purpose of this study was to examine client-rated appropriateness and preferences regarding the discussion of religious and spiritual concerns in group counseling. Participants were 164 group clients at nine university counseling centers nationwide. Clients volunteered to complete an online questionnaire about their experiences and opinions regarding religion and spirituality in group counseling. The majority of clients indicated that religious concerns are an appropriate topic for group counseling and reported a preference to discuss religious and spiritual concerns with their groups. Regression analyses examined predictors of client-rated (a) appropriateness of discussing religious concerns in group, (b) appropriateness of group leaders using religious or spiritual interventions, and (c) preferences for discussing religious and spiritual issues in group. The most consistent predictors of these ratings were client spirituality, client religious commitment, degree of spiritual struggles, and the frequency with which religion had already been discussed in the clients’ specific groups.