The relationship between childhood cruelty toward animals and subsequent aggressive offending was explored in 1,336 (1,154 male, 182 female) participants from the 11‐wave Pathways to Desistance study (Mulvey, 2013). Aggressive and income offending at Waves 1 through 10 were regressed onto a dichotomous measure of prior involvement in animal cruelty and four control variables (age, race, sex, early onset behavior problems) assessed at Wave 0 (baseline). Results indicated that childhood animal cruelty was equally predictive of aggressive and non‐aggressive (income) offending, a finding inconsistent with the hypothesis that cruelty toward animals desensitizes a person to future interpersonal aggression or in some way prepares the individual for interpersonal violence toward humans. Whereas a significant sex by animal cruelty interaction was predicted, there was no evidence that sex or any of the other demographic variables included in this study (age, race) consistently moderated the animal cruelty–subsequent offending relationship. On the other hand, two cognitive‐personality measures (interpersonal hostility, callousness/unemotionality) were found to successfully mediate the animal cruelty–subsequent offending relationship. Outcomes from this study imply that a causal nexus—partially or fully mediated by hostility, callousness/unemotionality, and other cognitive‐personality variables—may exist between childhood animal cruelty and subsequent offending, although the effect is not specific to violence. Aggr. Behav. 40:238–249, 2014. © 2013 Wiley Periodicals, Inc.