This special issue of the Journal of Personality focuses on the importance of considering both personality and relationship forces when examining physical and psychological health. The nine articles presented in this issue employed a variety of research designs, theoretical rationales, health outcomes, and advanced statistical methodologies in order to better understand how both individual differences and social factors are relevant to our health. These articles embody several prominent themes: Conscientiousness is a robust predictor of health; traits beyond the Five‐Factor Model should be considered in attempts to understand personality, relationships, and health; links among personality, relationships, and health begin early in life; and relationship transitions are consequential to health. It is hoped that these studies inspire personality researchers to consider the relationship context of health and relationship researchers to consider individual differences when attempting to understand health behaviors and outcomes.