Are International Framework Agreements potential mechanisms of cross-border labour regulation? For some scholars they are no more than ‘window-dressing’, for others they are effective instruments of transnational regulation. We argue that their effectiveness depends on their interconnection with other mechanisms of labour regulation. Drawing on a broad review of research and our own empirical data, we conclude that different institutional frameworks, different dominant actor groups and configurations, and also different modes of regulation and bargaining, lead to varying and sometimes contrasting outcomes.