In the ICT-dominated world, libraries are facing major challenges in an attempt to fulfil their functions. If libraries are to respond adequately to rapid and complex changes, they need highly skilled and motivated employees. As people are an organization’s greatest asset, human resource management in libraries should be given proper attention. Different questions related to job satisfaction are definitely crucial for efficient human resource management. This paper presents the results of research focused on the way in which librarians in Eastern Croatia perceive certain aspects of their work. The analysis shows that Eastern Croatian librarians have a relatively positive attitude to their work, but they are less satisfied with their social status, salary levels, working conditions, possibilities for further training, and interpersonal relations at work. To a large extent, the results of this study indicate that human resource management in Eastern Croatian libraries needs to be improved. Statistical methods were also used to examine the differences in librarians’ opinions with regard to gender, age, professional title and the type of libraries they work in.