The purpose of this study was to test the effect of cardiac educational program on the level of knowledge and adherence to healthy lifestyle among patients with coronary artery disease in the north of Jordan. Pretest–posttest design was used. Eighty-four patients completed the posttest questionnaire. Knowledge and adherence to healthy lifestyle were measured at baseline and at 1 month after the application of the program. Paired t-test was used to analyze the data. The results showed that the change in the mean knowledge scores (10.50), p < .01 was statistically significant 1 month after the application of the program. In addition, the change in the mean adherence to healthy lifestyle scores (33.30), p < .01 was statistically significant 1 month after the application of the cardiac educational program. Implementing cardiac educational programs help enhance knowledge and adherence to healthy lifestyle among patients with coronary artery disease in north of Jordan.