This study examined the determinants of Black parents’ intention to have their daughters receive the HPV vaccine. Relationships between behavioral beliefs regarding the HPV vaccine, HPV vaccine attitudes, and HPV vaccine intentions among Black parents were explored. A descriptive correlational design and mediation model were used to explain the hypothesized relationships. HPV parental attitudes were significantly related to vaccine intention (r = .865, p < .001). A significant relationship between HPV vaccine behavioral beliefs and HPV vaccine attitudes was found among Black parents (r = .239, p < .001). Parental vaccine attitudes completely mediated the relationship between HPV vaccine behavioral beliefs and parental HPV vaccine intention. Understanding relevant factors associated with parental intent to have their daughters vaccinated are essential to reducing opposition to the HPV vaccine and increase vaccination rates among Black female adolescents.