This study examined whether geographic differences in intentional homicide rates in Europe were a function of societies that exhibit Anomic cultural tendencies and an institutional imbalance, as guided by Institutional Anomie Theory. This research is temporally sensitive, taking into account these differences over a 15-year time period. Additionally, separate operations of the theory within developed and transitioning countries were tested, and various cultural–institutional configurations were uncovered that led to increases or decreases in homicide rates. While still restricted by a lack of guidance from Messner and Rosenfeld and inconsistency in past research on how to operationalize key concepts of Institutional Anomie Theory, this study significantly contributes to the literature by assessing core theoretical questions of the theory while employing appropriate measurement strategies.