Objective: I hypothesize that individuals with depression lack the motivation and physical capacity required to participate in politics due to somatic problems and feelings of hopelessness and apathy. Furthermore, I hypothesize that depression in adolescence can have negative downstream consequences for participation in young adulthood. Method: Using the 1998 General Social Survey and the National Longitudinal Study of Adolescent Health, I employ logistic regression and mediation analysis to test the relationship between depression and voting as well as adolescent depression and political participation. Results: The results show that both depression and adolescent depression reduce the probability of political participation. The effect of adolescent depression on political participation is mediated by educational attainment and partisan affiliation. Conclusion: Depression reduces participation and merits further attention as a political phenomenon. The possibility of depression as a disability is discussed, including potential efforts to boost participation among this group.