This study examined the effects of teaching the reframing of negative statements through self-management and video-feedback on social conversation in adults with autism spectrum disorder (ASD). A multiple baseline design across five participants showed that, following intervention, all were able to increase their positive and neutral statements while decreasing negative statements, with generalization to peers in new settings. In addition, four of the five participants’ affect and interest improved following the intervention, and three were rated as more socially desirable. Furthermore, post-treatment improvements were noted on standardized measures of depression, anxiety, and hopelessness. Results are discussed in terms of improving general social communicative interactions and quality of life in adults with ASD.