This research examines the partisan inclinations of American Indians, a minority population with a complicated history with the U.S. government and American society. The empirical analyses identify Native Americans as preferring the Democratic Party over the Republican Party. The impact of being Native American on identification with the Democratic Party is sizable, equivalent to the effect for being Hispanic, Asian, or female. In addition, American Indians demonstrate a pronounced tendency to not affiliate with a major American political party. The higher incidence of non-identification among Native Americans likely results from the importance of their claims for sovereignty and, relatedly, living separate from much of American society. Unlike other broad-based social groups in American politics, Native Americans disseminate cues that reduce the tendency of their members to affiliate with a major political party.