Students with disabilities (SWDs) depend upon special education teachers (SETs) to provide effective instruction. SETs, in turn, depend upon school leaders to provide conditions necessary to learn and engage in effective instructional practices for students with the most significant learning needs. A promising body of research indicates that working conditions such as administrative support and school culture influence general educators’ effectiveness and their students’ achievement. This literature review examines research investigating relationships between SETs’ working conditions and instructional quality and SWDs’ academic achievement, to provide insights into how working conditions might be leveraged to improve SETs’ instruction and SWDs’ achievement.