The press had great potential to influence perceptions of Sarah Palin during the 2008 campaign, given her relative obscurity when picked to be the Republican vice-presidential nominee. Prior literature on press treatment of women running for national office suggests that Palin was likely to receive coverage that disadvantaged her due to her gender. We scrutinize press coverage of Palin’s campaign for evidence that she was treated differently and that these differences affected public opinion. Our sample of over 2,500 individual newspaper articles published during the campaign is paired with the 2008 National Annenberg Election Survey. We demonstrate that Palin’s coverage differed in significant ways from that of her male counterpart. Her gender, appearance, and family status were disproportionately mentioned in her coverage, and such mentions tended to dampen public opinion about her. In addition, the tone of Palin’s coverage was markedly negative, increasingly so over time, and was significantly related to reader opinion about her. While Palin was a unique candidate for national-level office, these findings should give pause to those concerned with equitable press treatment of women on the campaign trail.