Based on 21 individual case studies, this article inventories the ways journalism deals with scientific uncertainty. The study identifies the decisions that impact a journalist’s perception of a truth claim as unambiguous or ambiguous and the strategies to deal with uncertainty that arise from this perception. Key for understanding journalistic action is the outcome of three evaluations: What is the story about? How shall the story be told? What type of story is it? We reconstructed the strategies to overcome journalistic decision-making uncertainty in those cases in which they perceived scientific contingency as a problem. Journalism deals with uncertainty by way of omission, by contrasting the conflicting messages or by acknowledging the problem via the structure or language. One finding deserves particular mention: The lack of focus on scientific uncertainty is not only a problem of how journalists perceive and communicate but also a problem of how science communicates.