Objective Given that many refugees are from culturally and linguistically diverse backgrounds and may have limited English language competency, health professionals must frequently work with interpreters to provide services to clients. This study aims to examine how working with an interpreter affects mental healthcare for refugee clients. In particular, the study aims to consider the perspectives and opinions of mental health practitioners who have worked with refugee clients with the help of an interpreter, along with identifying what factors play a role in enhancing or limiting the therapeutic alliance between mental health professionals and clients where an interpreter is mediating communication. Method Mental health professionals (specifically registered mental health social workers and clinical psychologists) working with refugees in South Australia were interviewed (N = 7). Data were analysed using thematic analysis, as part of a qualitative research paradigm. Results Analysis of the data identified the following key themes: “refugees are unique,” “interpreters are necessary and important,” “interpreters are important to the therapeutic alliance,” “interpreters can present challenges to therapy and therapeutic relationships,” and “training is a problem.” The supportive presence of interpreters, along with the multiple roles interpreters often adopt inside and outside the therapy room, were also highlighted as important in building strong therapeutic alliances. Conclusion This study found that interpreters were considered to be an integral part of providing mental healthcare to refugee clients, and sometimes contributed to the therapeutic alliance themselves. Future research could incorporate the experiences of interpreters and refugee clients to provide a more comprehensive perspective.