This article analyzes the development of the National Anthropological Film Center as an outgrowth of the Smithsonian's efforts to promote a multidisciplinary program in “urgent anthropology” during the 1960s and 1970s. It considers how film came to be seen as an ideal tool for the documentation and preservation of a wide range of human data applicable to both the behavioral and life sciences. In doing so, it argues that the intellectual and institutional climate facilitated by the Smithsonian's museum structure during this period contributed to the Center's initial establishment as well its eventual decline. Additionally, this piece speaks to the continued relevance of ethnographic film archives for future scientific investigations within and beyond the human sciences.