Patient falls cause economic loss in hospitals, as well as patient injuries. This study aimed to calculate the additional hospital cost and length of stay (LOS) due to fall-related serious injuries and to identify the determining factors for both outcomes. A matched case-control design was used in the study. It was conducted with a case group of 39 patients and a control group of 39 patients in 28 hospitals in Izmir, Turkey. The additional hospital cost and LOS due to fall-related serious injuries were calculated to be US$3,302.60 and 14.61 days, respectively. Precautionary initiatives for the injurious falls can prevent patients from getting injured and avoid increases in cost and LOS due to these injuries.