The article takes into consideration the spatialised action of self‐managed Social Centres in Northern Italy over the last 20 years. Considering Genoa, Turin and Milan, we outline the passage from the Fordist era to the post‐industrial cities reconversion, which gave the space—both physical and political—for the emergence of Social Centres. The changes that occurred in the three cities in the following years introduced new features in urban space configuration and organisation. In this frame, we focus on three case studies that serve the purpose of illustrating the role of Social Centres contesting unfair space transformations: Genoa's Expo Colombiane in 1992, Turin's Winter Olympic Games in 2006 and Milan's Expo in 2015. The opposition to these “mega‐events” allows us to analyse the changes related to the forms of conflict put into practice by urban social movements throughout time, and the learning process they underwent.