["Archives of Insect Biochemistry and Physiology, Volume 121, Issue 4, April 2026. ", "Chronic dietary advanced glycation end‐products (AGEs) induce multi‐system dysfunction in Drosophila melanogaster, including neuromuscular impairment, oxidative stress, DNA damage, apoptosis, and metabolic dysregulation resembling insulin resistance. These findings establish Drosophila as a valuable model for investigating AGE‐induced pathophysiology relevant to diabetes and neurodegenerative diseases.\n\n\n\n\n\nABSTRACT\nAdvanced glycation end‐products (AGEs) accumulate during hyperglycemia and contribute to metabolic and neurodegenerative complications. This study investigates the effects of AGEs on Drosophila melanogaster by evaluating locomotion, oxidative stress, DNA damage, and metabolic alterations. Flies subjected to an AGEs‐enriched diet exhibited erratic movement patterns, indicating neuromuscular dysfunction. Increased oxidative stress markers were observed, accompanied by significant DNA damage and disruptions in cell cycle progression, indicating genotoxic stress and the induction of apoptosis. Metabolic assessment revealed disrupted glucose and lipid homeostasis, suggesting insulin resistance and metabolic reprogramming. These findings reinforce D. melanogaster as an effective model for studying AGEs‐induced metabolic and neurodegenerative dysfunctions. Understanding the pathways involved in AGEs‐mediated toxicity could provide insights into AGEs‐related pathologies and potential therapeutic interventions."]