Safety and Feasibility of Hypodermoclysis in Advanced Cancer: A Systematic Review and Meta-Analysis

Muhanad Alzahrani, Abdullah Alabbasi, Muhannad Q. Alqirnas, Ziyad Alzahrani, Faris A. Sultan, Ministry of Health, Saudi Arabia, Saudi Board in Family Medicine, Ministry of Health, Saudi Arabia, Division of Plastic and Reconstructive Surgery, Department of Surgery, King Salman Hospital, Saudi Arabia, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Saudi Arabia, Department of Surgery, College of Medicine, King Saud University, Saudi Arabia

American Journal of Hospice and Palliative Medicine®

Published online on March 07, 2026

Abstract

American Journal of Hospice and Palliative Medicine®, Ahead of Print.
BackgroundClinically assisted hydration in advanced cancer remains controversial, with uncertainty regarding potential benefits and harms near the end of life. Hypodermoclysis offers a less invasive alternative to intravenous hydration, yet safety ...