Functional and Circulating Indicators of Endothelial Health and Their Associations With the American Heart Association’s Life’s Essential 8

James R. Cirillo, Kristen T. Stopfer, Mia K. DeCataldo, Anna L. Marsland, Matthew F. Muldoon, Mark R. Scudder, Peter J. Gianaros, Department of Psychology, University of Pittsburgh, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine

American Journal of Lifestyle Medicine

Published online on December 12, 2025

Abstract

American Journal of Lifestyle Medicine, Ahead of Print.
The American Heart Association’s Life’s Essential 8 (LE8) is comprised of both biological and behavioral measures, and it predicts cardiovascular disease (CVD). Presently, however, its relation to measures of endothelial function implicated in CVD risk is ...