APOE ε4 Allele and Methylation Patterns Linked to Cardiovascular Outcomes in Women With Breast Cancer

Emily K. Mewborn, Myeong-ga Cho, Kirk I. Erickson, Catherine M. Bender, Yvette Conley, School of Nursing, Department of Health Promotion and Development, University of Pittsburgh, Neuroscience Institute, AdventHealth Research Institute, School of Public Health, Department of Human Genetics, University of Pittsburgh

Biological Research For Nursing: Integrating Biobehavioral Research into Health Care

Published online on September 30, 2025

Abstract

Biological Research For Nursing, Volume 28, Issue 2, Page 177-186, April 2026.
DNA methylation affects gene expression. While the Apolipoprotein E (APOE) genotype impacts cardiovascular risk,APOEmethylation impact remains unknown, particularly in women with breast cancer (BC). This study explored associations ofAPOEmethylation ...