Review of Bleeding as Initial Presentation in Patients with Chronic Myeloid Leukemia

Mohammad ALTermanini, Omar Altrmanini, Abdulrhaman F. Al-Mashdali, Ashraf Ahmed, Sara Saeed, Mohamed Fawzi Mudarres, Mohamed Saeed, ElMustafa Abdalla, Dina Soliman, Kalpana Singh, Amin Saied, Motaz Almahmood, Aasir Suliman, Hanaa Qasim, Tareq Abuasab, Fadi Haddad, Mohamed Yassin, Shehab Fareed

Clinical and Applied Thrombosis/Hemostasis

Published online on April 27, 2026

Abstract

Clinical and Applied Thrombosis/Hemostasis, Volume 32, January-December 2026.
BackgroundChronic myeloid leukemia (CML) typically presents with fatigue, weight loss, leukocytosis, and splenomegaly. Major bleeding or spontaneous hematoma as the initial manifestation is rare and poses significant diagnostic and therapeutic challenges. ...